Evolution of DNA methylation is linked to genetic aberrations in 2 chronic lymphocytic leukemia

4 5 Christopher C. Oakes, Rainer Claus, Lei Gu, Yassen Assenov, Jennifer Hüllein, 6 Manuela Zucknick, Matthias Bieg, David Brocks, Olga Bogatyrova, Christopher R. 7 Schmidt, Laura Rassenti, Thomas J. Kipps, Daniel Mertens, Peter Lichter, 8 Hartmut Döhner, Stephan Stilgenbauer, John C. Byrd, Thorsten Zenz and 9 Christoph Plass 10 11 12 Affiliations: Division of Epigenomics and Cancer Risk Factors, Theoretical 13 Bioinformatics, Biostatistics and Molecular Genetics, The German Cancer Research 14 Center (DKFZ), Heidelberg, Germany; Department of Medicine, University of Freiburg 15 Medical Center, Freiburg, Germany; Department of Translational Oncology, National 16 Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), 17 Heidelberg, Germany; Department of Medicine V, University of Heidelberg, Heidelberg, 18 Germany; Department of Medicine, University of California at San Diego Moores 19 Cancer Center, La Jolla, USA; Department of Internal Medicine III, University of Ulm, 20 Ulm, Germany; Division of Hematology, The Ohio State University, Columbus, USA; 21 The German Cancer Consortium. 22